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Posted to michael.silverton.palo-alto.ca.us
Personalized Life Extension Conference 2010
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- longevity
- life extension
- foresight
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Posted to michael.silverton.palo-alto.ca.us
What telomeres are telling us: another p…
http://feedproxy.google.com/~r/packets/~3/Iu10HF1ZXIs/
What telomeres are telling us: another piece of the puzzle seems to be falling into place. Today, on Machines Like Us: A team led by researchers at Albert Einstein College of Medicine of Yeshiva University has found a clear link between living to 100 and inheriting a hyperactive version of an enzyme that rebuilds telomeres – the tip ends of chromosomes. The findings appear in the latest issue of the Proceedings of the National Academy of Sciences. Telomeres play crucial roles in aging, cancer and other biological processes. Their importance was recognized last month, when three scientists were awarded the 2009 Nobel Prize in Physiology and Medicine for determining the structure of telomeres and discovering how they protect chromosomes from degrading.
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Posted to google.com
Genescient Will Have will have Nutrigenomic Products, fully lab tested, by end of 2009
Gregory Benford will be presenting an update of Genescient's work at the Singularity Summit in New York on October 3rd and 4th, 2009.Our laboratory animals live for 5 times the normal lifespan. They have health and vigor. We use their genetic properties to find what works similarly in humans.Genescient applies 21st century genomic technology to identify, screen and develop benign therapeutic substances to defeat the diseases of aging. Genescient's singular approach addresses the complex genomic networks that underlie aging and aging-associated diseases such as cardiovascular disease, Type II diabetes and neurodegenerative diseases. We will have nutrigenomic products, fully lab tested, by end of 2009Genescient has released a research paper detailing their study of two common stimulants (caffeine and the stimulant in chocolate) and two common sedatives (valproic acid and lithium).Genescient has found that caffeine consistently impaired mating success in experiments. By contrast, at normal doses theobromine (the chief stimulant in chocolate) was benign. Worse still, caffeine impaired survival and female reproduction. Again, theobromine proved relatively benign for survival and reproduction.Genescient corporate overviewOur focus is to extend healthy human lifespan by using advanced genomics to develop therapeutic substances that attack the diseases of aging. We are the first company founded to exploit artificial selection of animal models for longevity.Our extremely long-lived animal models (Drosophila melanogaster) have been developed over 700 generations. They are an ideal system for the study of aging and age-related disease because Drosophila metabolic genetic pathways that are highly conserved in humans.Our sophisticated analysis cross-links gene function in Drosophila with their human orthologs, thus revealing the targets for therapeutic substance development. To date we have discovered over 100 of these genomic targets, all related to the primary diseases of aging.This large library of targets, enables Genescient to effectively select and test therapeutic drug candidates. To date, Genescient’s “proof-of-concept” testing program has yielded a number of very promising therapeutic substances.Genescient’s screening platform also enables us to partner with biotechnology and pharmaceutical companies to test and rapidly move forward promising drug candidates. In an era where drug failure at a late clinical trial phase can cost a company hundreds of millions of dollars, Genescient’s unparalleled screening technology helps pharmaceutical companies to rapidly eliminate poor candidates.
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Posted to michael.silverton.palo-alto.ca.us
Tests Begin on Drugs That May Slow Aging
Full story at The New York Times:
"In caloric restriction, mice are kept on a diet that is healthy but has 30 percent fewer calories than a normal diet. The mice live 30 or 40 percent longer than usual with the only evident penalty being that they are less fertile.
People find it almost impossible to maintain such a diet, so this recipe for longevity remained a scientific curiosity for many decades. Then came the discovery of the single gene changes, many of which are involved in the body’s regulation of growth, energy metabolism and reproduction. The single gene changes thus seem to be pointing to the same biochemical pathways through which caloric restriction extends life span." -
Posted to michael.silverton.palo-alto.ca.us
Old News: Caloric Restriction Improves Memory in the Elderly
Caloric Restriction Improves Memory in the Elderly
The good news for caloric restriction just keeps coming. While optimal anti-aging benefits may require starting caloric restriction during early adulthood, good things will apparently come to those who cut their calorie intake after middle age too. -
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The Mechanisms by Which Excess Fat Harms You (via feedly)
http://www.longevitymeme.org/news/view_news_item.cfm?news_id=4300
Shared by @silverton
It's the inflammation. For the overly analytical -- none of those kind around here, I know -- it's sometimes the process of learning and internalizing the clinical why and how of various health risks that can organically catalyze the will to explore new behaviors and even change just a few key variables to find a more sustainable path; one that is source of Constant Accomplishment rather than an Eternal Battle of sheer will. Facing this lifelong struggle myself, on this front, I surely wish us each All The Best ...
Excess fat leads to chronic inflammation and damage over time. From ScienceDaily: "Fat tissue is no longer considered simply a storage place for excess calories, but in fact is an active tissue that secretes multiple compounds, thereby communicating with other tissues, including the liver, muscles, pancreas and the brain. Normal communication is necessary for optimal metabolism and weight regulation. However, in obesity, fat (adipose) tissue becomes dysfunctional, and mis-communicates with the other tissues. This places fat tissue at a central junction in mechanisms leading to common diseases attributed to obesity, like type 2 diabetes and cardiovascular diseases. ... Fat tissue dysfunction is believed to be caused by obesity-induced fat tissue stress: Cells over-grow as they store increasing amounts of fat. This excessive cell growth may cause decreased oxygen delivery into the tissue; individual cells may die (at least in mouse models), and fat tissue inflammation ensues. Also, excess nutrients (glucose, fatty acids) can also result in increased metabolic demands, and this in itself can cause cellular stress." You might also look at the role of macrophages in fat-induced inflammation.
View the Article Under Discussion: http://www.sciencedaily.com/releases/2009/07/090714125002.htm Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/ [extracted from The Mechanisms by Which Excess Fat Harms You via feedly]
For more information, consider the CR Lifestyle.
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Posted to delicious.com
The secret of longevity: no food, no husband and no regrets - Times Online
http://women.timesonline.co.uk/tol/life_and_style/women/article6163496.ece
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- longevity
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Posted to delicious.com
The secret of longevity: no food, no husband and no regrets - Times Online
http://women.timesonline.co.uk/tol/life_and_style/women/article6163496.ece
- Tags:
- longevity
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